Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity
IR@IICT: CSIR-Indian Institute of Chemical Technology, Hyderabad
View Archive Info| Field | Value | |
| Creator |
Kurumurthy, C
Rao, P.S Veera swamy, B Kumar, G.S Rao, P.S Narsaiah, B Velatooru, L.R Pamanji, R Rao, J.V |
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| Date |
2012-11-08T05:48:05Z
2012-11-08T05:48:05Z 2011 |
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| Identifier |
Fuel Processing Technology 1411-1417:92(8)
http://hdl.handle.net/123456789/8202 |
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| Description |
A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting
from 2,3-active functional pyridine 1 via cyclization, propargylation followed by reaction with alkyl or
perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for anticancer
activity against three cancer cell lines such as U937, THP-1 and Colo205. The promising compounds
5b and 5e have been identified.
IICT |
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| Language |
en
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| Publisher |
Elsevier
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| Subject |
Pyrido[2,3-d]pyrimidine
Cyclisation Propargylation Perfluoroalkyl azides Sharpless conditions Anticancer activity |
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| Title |
Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity
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| Type |
Article
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