Triazino indole-Quinoline hybrid: A novel approach to Antileishmanial agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sharma, Rashmi
Pandey, A K Shivahare, Rahul Srivastava, Khushboo Gupta, Suman Chauhan, P M S |
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| Date |
2014-04-25T07:41:05Z
2014-04-25T07:41:05Z 2014 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters, 2014, 24(1), 298-301
http://hdl.handle.net/123456789/1214 |
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| Description |
A novel series of 1,2,4-triazino-[5,6b]indole-3-thione covalently linked to 7-chloro-4-aminoquinoline have been synthesized and evaluated for their in vitro activity against extracellular promastigote and intracellular amastigote form of Leishmania donovani. Among all tested compounds, compound 7a and 7b was found to be the most active with IC50 values 1.11, 0.36 μM and selectivity index (SI) values 67, >1111 respectively against amastigote form of L. donovani which is several folds more potent than the standard drugs, miltefosine (IC50 = 8.10 µM, SI = 7) and sodium stibo-gluconate (IC50 = 54.60 µM, SI = >7).
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| Format |
196155 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8565
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| Subject |
Antileishmanial
Hybrid In vitro Leishmania donovani Quinoline Triazino-indole |
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| Title |
Triazino indole-Quinoline hybrid: A novel approach to Antileishmanial agents
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| Type |
Article
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