Synthesis of new N-acryl-1-amino-2-phenylethanol and N-acyl-1-amino-3-aryloxypropanols and evaluation of their antihyperlipidemic, LDL-oxidation and antioxidant activity
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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Creator |
Sarkar, Satinath
Sonkar, Ravi Bhatia, Gitika Tadigoppula, Narender |
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Date |
2014-07-09T08:58:19Z
2014-07-09T08:58:19Z 2014 |
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Identifier |
European Journal of Medicinal Chemistry, 2014, 80,135 -144
http://hdl.handle.net/123456789/1305 |
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Description |
As a part of our drug discovery program, we identified an alkaloidal amide i.e Aegeline (V) isolated from the leaves of Aegle marmelos as a dual acting agent (antihyperlipidemic and antihyperglycemic). In continuation of this program, we synthesized new N-acyl-1-amino-2-alcohols (N-acrylated-1-amino-2-phenylethanol and N-acylated-1-amino-3-aryloxypropanols) via Ritter reaction and screened for their in-vivo antihyperlipdemic activity in Triton induced hyperlipidemia model, LDL-oxidation and antioxidant activity. Compounds 3, 11 and 13 showed good antihyperlipidemic activity, LDL-oxidation as well as antioxidant activity and comparable activity with marketed antidyslipidemic drug.
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443874 bytes
application/pdf |
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Language |
en
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Relation |
CSIR-CDRI Communication no. 8655
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Subject |
Aegeline
N-Acyl-1-Amino-2-Alcohols Antihyperlipidemic Activity LDL-Oxidation Anti-Oxidant Activity Triton Model |
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Title |
Synthesis of new N-acryl-1-amino-2-phenylethanol and N-acyl-1-amino-3-aryloxypropanols and evaluation of their antihyperlipidemic, LDL-oxidation and antioxidant activity
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Type |
Article
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