Furan based Locked Z-Vinylogous γ-Amino Acid Stabilizing Pro-tein α-Turn in Water-Soluble Cyclic α3γ Tetrapeptides
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Krishna, Yarkali
Sharma, Shrikant Ampapathi, R S Koley, Dipankar |
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| Date |
2014-08-11T07:14:48Z
2014-08-11T07:14:48Z 2014 |
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| Identifier |
Organic Letters, 2014, 16(8), 2084-7
http://hdl.handle.net/123456789/1351 |
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| Description |
Described here is the design, synthesis and conformational analysis of cyclic tetrapeptides (CTPs) with α3γ architecture containing a furan based locked Z-vinylogous amino acid (Vaa). This unnatural amino acid locks into a γ-turn that induces type IαRS-turn in the CTPs. Stabilized by a 13-membered intramole-cular H-bond these CTPs show robust conformation in water and aprotic solvent irrespective of the se-quence of tripeptide consisting of α-amino acids used.
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| Format |
1192444 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8641
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| Subject |
Z-Vinylogous
γ-Amino Acid Protein α3γ Tetrapeptides |
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| Title |
Furan based Locked Z-Vinylogous γ-Amino Acid Stabilizing Pro-tein α-Turn in Water-Soluble Cyclic α3γ Tetrapeptides
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| Type |
Article
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