A rapid entry to amino acids derived diverse 3,4-dihydropyrazines and ihydro[1,2,3]triazolo[1,5-a]pyrazines through 1,3-dipolar cycloaddition
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Bera, Saurav
Panda, Gautam |
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| Date |
2014-08-12T06:35:16Z
2014-08-12T06:35:16Z 2014 |
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| Identifier |
Organic & Biomolecular Chemistry. 2014, 12(23), 3976-85
http://hdl.handle.net/123456789/1360 |
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| Description |
An efficient, general and practical synthesis of diverse 3,4-dihydropyrazines, 6,7-dihydro-[1,2,3]triazolopyrazines and 7,8-dihydro-[1,2,3]triazolodiazepines through intramolecular 1,3-dipolar cycloaddition from amino acids derived common intermediate with high yields is described. Moreover, one-pot access to optically active 3-aryl substituted 6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazines under palladium–copper co-catalytic system has also been achieved in this work. The easy substrate availability and operational simplicity make the process suitable for further exploration.
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| Format |
207313 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8659
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| Subject |
Amino acids
Dipolar cycloaddition |
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| Title |
A rapid entry to amino acids derived diverse 3,4-dihydropyrazines and ihydro[1,2,3]triazolo[1,5-a]pyrazines through 1,3-dipolar cycloaddition
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| Type |
Article
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