Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Bhosale, V V
Inamdar, S C Karande, V B Burute, S R Murthy, M B Ghatak, A |
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| Date |
2014-08-29T06:06:29Z
2014-08-29T06:06:29Z 2014 |
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| Identifier |
Journal of Clinical and Diagnostic Research, 2014, 8 (6), HC01 - HC04
http://hdl.handle.net/123456789/1384 |
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| Description |
Introduction: Hypertension, “The silent killer” is a multifactorial disorder which is asymptomatic and if left untreated leads to lethal complications. Nebivolol is a third generation beta blocker with additional vasodilating property due to nitric oxide release. Aim: The current study aims to assess efficacy and safety of Nebivolol and compare with Atenolol. Methods: This was prospective, double blind, comparative controlled clinical study. Total 90 patients were enrolled into study as per selection criteria. Patients were randomized to receive Atenolol and Nebivolol with 45 patients in each group for twelve week. Results and Conclusion: The mean reduction diastolic blood pressure in Nebivolol and Atenolol group was 10.77±2.60 and 10.05±2.83 respectively. The number of patients with adverse effect events was higher in the Atenolol than in the Nebivolol group (36.84% of Atenolol Vs 12.82% of Nebivolol). Thus it can be concluded that, for the same antihypertensive effect, Nebivolol was better tolerated than Atenolol.
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133019 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8682
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| Subject |
Hypertension
Nebivolol Atenolol |
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| Title |
Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension
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| Type |
Article
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