Synthesis and Biotinylation of Oligosaccharide Fragments of Mannosylated and 5-Deoxy-5-methylthio-xylofuranosylated Lipoarabinomannan from Mycobacterium tuberculosis
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Mandal, P K
Chheda, P R |
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| Date |
2015-03-20T11:31:56Z
2015-03-20T11:31:56Z 2015 |
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| Identifier |
Carbohydrate Research, 2015, 407, 104-110.
http://hdl.handle.net/123456789/1434 |
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| Description |
The attachment of biotin to a molecule provides a powerful tool in biology. Here, we report an efficient synthesis and biotinylation of mannosylated and 5-deoxy-5-methylthio-xylofuranosylated Lipoarabinomannan from Mycobacterium tuberculosis. Preparation of the oligosaccharides involved the sequential addition of thioglycoside donors with arabinofuranosyl-containing acceptors. Methylthio group was introduced near the end of the synthesis.
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293709 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8889
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| Subject |
Tuberculosis(TB)
5-deoxy-5-methylthio-xylofuranose (MTX) Glycosylation Biotin Lipoarabinomannan (LAM) |
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| Title |
Synthesis and Biotinylation of Oligosaccharide Fragments of Mannosylated and 5-Deoxy-5-methylthio-xylofuranosylated Lipoarabinomannan from Mycobacterium tuberculosis
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| Type |
Article
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