Insulin-degrading enzyme: A link between Alzheimer’s and type 2 diabetes mellitus
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Haque, Rizwanul
Nazir, Aamir |
|
| Date |
2015-03-23T08:16:07Z
2015-03-23T08:16:07Z 2014 |
|
| Identifier |
CNS & Neurological Disorders - Drug Targets, 2014, 13(2), 259-64.
http://hdl.handle.net/123456789/1439 |
|
| Description |
Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer’s Disease (AD). Recent studies provide inkling for the use of IDE as a potential target, hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes and Alzheimer’s disease and the approaches, that make IDE a potential target, are discussed.
|
|
| Format |
200242 bytes
application/pdf |
|
| Language |
en
|
|
| Relation |
CSIR-CDRI Communication No. 8881
|
|
| Subject |
IDE
Alzheimer’s disease Type 2 Diabetes Caenorhabditis elegans |
|
| Title |
Insulin-degrading enzyme: A link between Alzheimer’s and type 2 diabetes mellitus
|
|
| Type |
Article
|
|