Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Ramakrishna, K K G
Gunjan, Sarika Shukla, A K Pasam, V R Balaramnavar, V M Sharma, Abhisheak Jaiswal, Swati Lal, Jawahar Tripathi, Renu Srivastava, Anubhooti Ramachandran, Ravishankar Tripathi, R P |
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| Date |
2015-03-30T10:27:58Z
2015-03-30T10:27:58Z 2014 |
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| Identifier |
ACS Medicinal Chemistry Letters, 2014, 5 (8), 878–883
http://hdl.handle.net/123456789/1442 |
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| Description |
A new series of C- linked phenyl butenonyl glycosides bearing ureidyl(thioureidyl) and sulfonamidyl moieties in the phenyl rings were designed, synthesized and evaluated for their in vitro antimalarial activities against Plasmodium falciparum 3D7 (CQ sensitive) and K1 (CQ resistant) strains. Among all the compounds screened the C- linked phenyl butenonyl glycosides bearing sulfonamidyl moiety (5a) and ureidyl moiety in the phenyl ring (7d and 8c) showed promising antimalarial activities against both 3D7 and K1 strains with IC50 values in µM range and low cytotoxicity offering new HITS for further exploration
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6721794 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI communication No. 8709
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| Subject |
Antimalarial agent
Phenyl sulfonamides Diarylureides Plasmodium falciparum |
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| Title |
Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents
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| Type |
Article
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