Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Chhonker, Y S
Prasad, Y D Chandasana, Hardik Vishvkarma, Akhilesh Mitra, Kalyan Shukla, P K Bhatta, R S |
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| Date |
2015-05-13T08:25:07Z
2015-05-13T08:25:07Z 2015 |
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| Identifier |
International Journal of Biological Macromolecules, 2015, 72, 1451–1458
http://hdl.handle.net/123456789/1451 |
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| Description |
Fungal keratitis is the major cause of vision loss worldwide. Amphotericin-B is considered as the drug of choice for fungal infections. However, its use in ophthalmic drug delivery is limited by the low precorneal residence at ocular surface as a result of blinking reflex, tear turnover and nasopharyngeal drainage. We report Amphotericn-B loaded lecithin/chitosan nanoparticles for prolonged ocular application. The prepared nanoparticles were in the size range of 161.9–230.5 nm, entrapment efficiency of 70–75%, theoretical drug loading of 5.71% with positive zeta potential of 26.6–38.3 mV. As demonstrated by antifungal susceptibility against Candida albicans and Aspergillus fumigatus, nanoparticles were more effective than marketed formulation. They exhibited pronounced mucoadhesive properties. In-vivo pharmacokinetic studies in New Zealand albino rabbit eyes indicated improved bioavailablity (~2.04 fold) and precorneal residence time (~3.36 fold) of nanoparticles prepared from low molecular weight of chitosan as compared with marketed formulation.
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| Format |
504432 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8807
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| Subject |
Fungal keratitis
Amphotericin-B Lecithin/chitosan nanoparticles |
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| Title |
Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application
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| Type |
Article
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