Copper(II)-Mediated Intermolecular C(sp2)−H Amination of Benzamides with Electron-Rich Anilines
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Copper(II)-Mediated Intermolecular C(sp2)−H Amination of
Benzamides with Electron-Rich Anilines
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| Creator |
Singh, Bijaya Kumar
Polley, Arghya Jana, Ranjan |
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| Subject |
Chemistry
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| Description |
Despite significant progress, copper-catalyzed/
mediated C−H amination reactions with electron-rich anilines
remain an unsolved problem due to catalyst deactivation and
deleterious side reactions. Herein, we report a copper(II)-
mediated C(sp2)−H amination of benzamides with electronically neutral or electron-rich anilines. A dramatic influence of silver(I) and tetrabutylammonium bromide was observed on the reaction outcome. The present protocol also demonstrates the synthesis of a number of nonsteroidal anti-inflammatory
drugs.
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| Publisher |
American Chemical Society
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2532/1/The_Journal_of_Organic_Chemistry.pdf
Singh, Bijaya Kumar and Polley, Arghya and Jana, Ranjan (2016) Copper(II)-Mediated Intermolecular C(sp2)−H Amination of Benzamides with Electron-Rich Anilines. The Journal of Organic Chemistry, 81. 4295-4303. |
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| Relation |
http://dx.doi.org/10.1021/acs.joc.6b00659
http://www.eprints.iicb.res.in/2532/ |
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