A Conserved Helicobacter pylori Gene, HP0102, Is Induced Upon Contact With Gastric Cells and Has Multiple Roles in Pathogenicity
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
A Conserved Helicobacter pylori Gene, HP0102, Is Induced
Upon Contact With Gastric Cells and Has Multiple Roles
in Pathogenicity
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| Creator |
Bhattacharya, Saurabh
Mukherjee, Oindrilla Mukhopadhyay, Asish K Chowdhury, Rukhsana |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Contact with host cells is recognized as a signal capable of triggering expression of bacterial genes important for host pathogen interaction.Adherence of Helicobacter pylori to the gastric epithelial cell line AGS strongly upregulated expression of a gene, HP0102,in the adhered bacteria in all strains examined, including several Indian clinical isolates. The gene is highly conserved and ubiquitously present in all 69 sequenced H. pylori genomes at the same genomic locus, as well as in 15 Indian clinical isolates. The gene is associated with 2 distinct phenotypes related to pathogenicity. In AGS cell–adhered H. pylori, it has a role in upregulation of cagA expression from a specific σ28-RNAP promoter and consequent induction of the hummingbird phenotype in the infected AGS cells.
Furthermore, HP0102 has a role in chemotaxis and a ΔHP0102 mutant exhibited low acid-escape response that might account for the poor colonization efficiency of the mutant
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| Publisher |
University of Chicago Press
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2545/1/NAL_OF_INFECTIOUS_DISEASES.pdf
Bhattacharya, Saurabh and Mukherjee, Oindrilla and Mukhopadhyay, Asish K and Chowdhury, Rukhsana (2016) A Conserved Helicobacter pylori Gene, HP0102, Is Induced Upon Contact With Gastric Cells and Has Multiple Roles in Pathogenicity. The Journal of Infectious Diseases, 214. pp. 196-204. |
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| Relation |
http://dx.doi.org/10.1093/infdis/jiw139
http://www.eprints.iicb.res.in/2545/ |
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