CSIR Central

One-tenth dose of LC50 of 4-tert-butylphenol causes endocrine disruption and metabolic changes in Cyprinus carpio

IR@NEERI: National Environment Engineering Research Institute


Field	Value

Title	One-tenth dose of LC50 of 4-tert-butylphenol causes endocrine disruption and metabolic changes in Cyprinus carpio

Creator	Barse, A V Chakrabarti, T Ghosh, T K Pal, A K Jadhao, S B

Subject	Biochemistry

Description	Of the huge annual worldwide production (500,000 MT in 1997) of alkylphenol polyethoxylates (APEs) that are widely used as nonionic surfactants and anti-oxidants in variety of products, 60% ends up in water bodies. They undergo biodegradation to form octyl-,butyl-, and nonyl-phenols. This experiment evaluated eVects of 4-tert-butyl phenol (4-TBP) in Cyprinus carpio, a projected candidate species in sewage fed Wsheries. The 96th h LC50 of 4-TBP was found to be 6.9mg/L. Fishes were treated with 1/10th (0.69mg/L), 1/5th (1.38mg/L), and 1/3rd (2.3mg/L) dose of LC50. Whereas there was signiWcant (P< 0.01) decrease in alkaline phosphatase [EC 3.1.3.1] and aspartate aminotransferase [EC 2.6.1.1] activity; alanine aminotranferase [EC 2.6.1.2] and acid phosphatase [3.1.3.2] (except decrease at 1/10th dose of LC50) activity, vitellogenin production in muscle and hepatic- and reno-somatic indices were increased compared to control. With all the dose levels tested, testicular-somatic index (testis size) was reduced (P< 0.01) and histo-architectural changes in testicular and liver tissue were found even in group given 1/3rd dose of LC50.

Publisher	Elsevier

Date	2006-05-03

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://neeri.csircentral.net/30/1/Barse1.pdf Barse, A V and Chakrabarti, T and Ghosh, T K and Pal, A K and Jadhao, S B (2006) One-tenth dose of LC50 of 4-tert-butylphenol causes endocrine disruption and metabolic changes in Cyprinus carpio. Pesticide Biochemistry & Physiology, 86. pp. 172-179.

Relation	http://neeri.csircentral.net/30/