Tailored poly(ethylene) glycol dimethacrylate based shape memory polymer for orthopedic applications
IR@NAL: CSIR-National Aerospace Laboratories, Bangalore
View Archive Info| Field | Value | |
| Title |
Tailored poly(ethylene) glycol dimethacrylate based shape memory polymer for orthopedic applications
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| Creator |
Antony, G Jerald Maria
Jarali, Chetan S Aruna, ST Raja, S |
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| Subject |
Aeronautics (General)
Chemistry and Materials (General) |
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| Description |
Shape-memory polymers (SMPs) are stimuli-responsive materials known for their outstanding ability to be
actuated from temporary shape into original shape. Because of this unique functionality SMPs are promising materials for diverse technological applications including smart biomedical devices. In this article, the work has been focused towards tailoring the SMP precursor and crosslinker wt% to obtain biocompatible acrylate based shape memory polymer with glass transition temperature (Tg) close to human body temperature. Methacrylate based shape memory polymer networks are synthesized via free radical polymerization by varying the wt% of tbutyl acrylate (tBA) and poly(ethylene glycol) dimethacrylate (PEGDMA) as crosslinker. The Tg is found to increase from 28 to 45 °C with increasing tBA amount. The SMP synthesized from 70 wt% of tBA and 30 wt% of PEGDMA possess Tg close to human body temperature and is tested for cytotoxicity with two different cell lineages, osteosarcoma (MG-63) cells, and human keratinocyte (HaCaT) cells. The synthesized SMP is found to be non-cytotoxic. Thus the investigated biocompatible shape memory polymer network can be a promising soft substrate for passive thermomechanical stimulation which can adapt and meet specific needs of in vitro or in vivo orthopedic Superior Labrum Anterior and Posterior (SLAP) medical devices.
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| Publisher |
Elsevier Ltd.,
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| Date |
2016
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| Type |
Journal Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://nal-ir.nal.res.in/12528/1/Jerald_paper%2D1.pdf
Antony, G Jerald Maria and Jarali, Chetan S and Aruna, ST and Raja, S (2016) Tailored poly(ethylene) glycol dimethacrylate based shape memory polymer for orthopedic applications. Journal of the Mechanical Behavior of Biomedical Materials, 65 . pp. 857-865. ISSN 1751-6161 |
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| Relation |
http://dx.doi.org/10.1016/j.jmbbm.2016.10.011
http://nal-ir.nal.res.in/12528/ |
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