A Mechanistic Approach to Determine the Anticancer and Antimetastatic Potential of Attenuated Strain of L. Donovani and Its Membrane Lipoprotein Via Regulation of Different Immunological Factors
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
A Mechanistic Approach to Determine the Anticancer and
Antimetastatic Potential of Attenuated Strain of L. Donovani and Its Membrane Lipoprotein Via Regulation of Different Immunological Factors
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| Creator |
Bose, Dipayan
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| Subject |
Cancer Biology and Inflammatory Disorder Division
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| Description |
Each year, millions of people are diagnosed worldwide with cancer, and more than half of these patients eventually die from this disease. In 2015, 27.9 million new cancer cases were diagnosed, and the number of deaths caused by this disease reached 16.7 million.Conventional cancer treatments, such as surgery, chemotherapy, and radiotherapy, often fail to achieve a complete cancer remission. Moreover, it has been widely recognized that radiotherapy and/or chemotherapy are likely to cause significant side effects. This has prompted the
development of many new approaches for the treatment of cancer. One such example involves the use of live or heat-killed attenuated microbes or their purified products. The use of microbial products for the treatment of cancer was pioneered by Dr. William B. Coley, who in 1891 treated patients with cancer with intra-tumoural injections of live Streptococcus pyogenes and,
subsequently, with mixtures of S. pyogenes and Serratia marcescens. The use of biotherapy reduced the cytotoxic side effects of the chemotherapeutic drugs and also was found to raise an immune response. For example, BCG which was earlier only used as a vaccine against
mycobacterium was successfully used in different cancers including acute lymphoblastic leukemia, melanoma, bladder cancer and etc. In the late 90s, biotherapy became very popular when different microbial cellular components mainly the membrane proteins and lipids were also
found to be highly potent against different cancers. Azurin and FTY720 are two membrane components that are already being patented and being approved by FDA as drugs against cancer and immune suppressive diseases
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| Date |
2016
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2722/1/Dipayan_Bose__Thesis.pdf
Bose, Dipayan (2016) A Mechanistic Approach to Determine the Anticancer and Antimetastatic Potential of Attenuated Strain of L. Donovani and Its Membrane Lipoprotein Via Regulation of Different Immunological Factors. PhD thesis, C U. |
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| Relation |
http://www.eprints.iicb.res.in/2722/
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