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Label-free immunosensing by long period fiber gratings at the lowest order cladding mode and near turn around point

IR@CGCRI: CSIR-Central Glass and Ceramic Research Institute, Kolkata

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Title Label-free immunosensing by long period fiber gratings at the lowest order cladding mode and near turn around point
 
Creator Dey, Tanoy Kumar
Tombelli, Sara
Biswas, Palas
Giannetti, Ambra
Basumallick, Nandini
Baldini, Francesco
Bandyopadhyay, Somnath
Trono, Cosimo
 
Subject Processing Science
 
Description A long period fiber grating has been fabricated by combining two sensitivity enhancement techniques, the turn around point (TAP) and the maximum enhancement of the evanescent field by obtaining the lowest order cladding mode (LP0,2 cladding mode). A label-free immunoglobulin G/anti immunoglobulin G (IgG/anti-IgG) immunoassay in serum has been performed with the sensor inside a thermostated closed flow cell. Real time kinetics of the IgG and anti-IgG binding has been monitored and evaluated. By measuring the dual peak resonance of the LP0,2 cladding mode, a limit of detection of 0.16 ng/ml (1.06 pM) for anti-IgG has been achieved.
 
Publisher Elsevier
 
Date 2021
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://cgcri.csircentral.net/5294/1/nandini.pdf
Dey, Tanoy Kumar and Tombelli, Sara and Biswas, Palas and Giannetti, Ambra and Basumallick, Nandini and Baldini, Francesco and Bandyopadhyay, Somnath and Trono, Cosimo (2021) Label-free immunosensing by long period fiber gratings at the lowest order cladding mode and near turn around point. Optics and Laser Technology, 142. Art No-107194. ISSN 0030-3992
 
Relation http://cgcri.csircentral.net/5294/