Understanding the mechanism of cardiac gene remodelling via PPAR-α signalling in cardiac hypertrophy
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Understanding the mechanism of cardiac gene
remodelling via PPAR-α signalling in cardiac
hypertrophy
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| Creator |
KUMARI, RITU
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| Subject |
Molecular & Human Genetics
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| Description |
identified and unveiled the functional relevance of differentially
expressed miRNAs in ISO-treated PPAR α-/- mice. As of now, limited literature was
available about miRNA abundance and their altered expression in cardiac hypertrophy
models in the absence of PPAR α protein. So for the very first time, using PPAR α-/- mice,
we showed that several miRNAs are differentially expressed that have never been reported in
context to cardiac hypertrophy. Additionally, pathway analysis, indicated that the
dysregulated miRNAs target genes were enriched mostly in signal transduction pathways.
Overall, our findings suggest the miRNAs expression profile of miRNAs like mmu-miR3102-5p; mmu-miR-30a-5p; mmu-miR-30c-5p; mmu-miR-466i-5p is significantly altered in
response to cardiac hypertrophy in PPAR-/- mice that eventually impacts the apoptotic
pathway in a negative manner.
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| Date |
2022
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2831/1/RITU_KUMAR_FINAAL_thesis.pdf
KUMARI, RITU (2022) Understanding the mechanism of cardiac gene remodelling via PPAR-α signalling in cardiac hypertrophy. PhD thesis, JADAVPUR UNIVERSITY. |
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| Relation |
http://www.eprints.iicb.res.in/2831/
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