Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Creator |
Kaur, P
Chandel, M Kumar, S Kumar, N Singh, B Kaur, S |
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| Subject |
Food Science & Technology; Toxicology
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| Description |
Rubia cordifolia L (Rubiaceae) is an important medicinal plant used in the Ayurvedic medicinal system. Its use as a traditional therapeutic has been related to the treatment of skin disorders and cancer. Besides it, medicinal value, anthraquinones from this plant are used as natural food colourants and as natural hair dyes. Dyes derived from natural sources have emerged as important alternatives to synthetic dyes. Alizarin (1,2-dihydroxyanthraquinone) was isolated and characterized from R. cordifolia L. and evaluated for its antigenotoxic potential against a battery of mutagens viz. 4-nitro-o-phenylenediamine (NPD) and 2-aminofluorene (2-AF) in Ames assay using TA98 tester strain of Salmonella typhimurium; hydrogen peroxide (H(2)O(2)) and 4-nitroquinoline-1-oxide (4NQO) in SOS chromotest using PQ37 strain of Escherichia coli and in Comet assay using human blood lymphocytes. Our results showed that alizarin possessed significant modulatory role against the genotoxicity of mutagens. (c) 2009 Elsevier Ltd. All rights reserved.
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| Publisher |
PERGAMON-ELSEVIER SCIENCE LTDOXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
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| Date |
2011-09-20T12:08:59Z
2011-09-20T12:08:59Z 2010 |
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| Type |
Article
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| Identifier |
FOOD AND CHEMICAL TOXICOLOGY
0278-6915 http://hdl.handle.net/123456789/13590 |
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| Language |
English
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