Statistical modeling of ultrastructural features of murine dermal collagen under chronic low-dose whole body X-irradiation
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Statistical modeling of ultrastructural features of murine dermal collagen under chronic low-dose whole body X-irradiation
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| Creator |
Chatterjee, J
Mukherjee, A Mukherjee, K Dutta, PK Chaudhuri, K |
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| Subject |
Biochemistry & Molecular Biology; Biophysics; Cell Biology
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| Description |
The present study investigated the changes in ultrastructural features of dermal collagen fibrils of mice following exposure to different cumulative chronic low-dose X-irradiation through digital image analysis-based statistical modeling. Pubertal mice were X-irradiated and dorsal skin biopsies were collected and processed for transmission electron microscopic (TEM) analysis. TEM features of collagen fibrils showed alteration in the cross-sectional area, population density and in the axial periodic pattern of light and dark bands. The mathematical analysis of histogram data from TEM images revealed some adaptive behavior in collagen structures of the X-irradiated group. This finding indicated that exposure to chronic low-dose X-radiation induced an altered steady state with adaptive variation in dermal collagen fibrils in irradiated mice. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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| Publisher |
ELSEVIER SCIENCE BVAMSTERDAMPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
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| Date |
2011-09-20T12:12:26Z
2011-09-20T12:12:26Z 2007 |
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| Type |
Article
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| Identifier |
FEBS LETTERS
0014-5793 http://hdl.handle.net/123456789/14273 |
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| Language |
English
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