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Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism

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Title Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism
 
Creator Senthilkumar, KS
Saravanan, KS
Chandra, G
Sindhu, KM
Jayakrishnan, A
Mohanakumar, KP
 
Subject Behavioral Sciences; Neurosciences
 
Description Dopaminergic functional recovery following controlled release of dopamine from biodegradable polymer matrices implanted in the lesioned striaturn was investigated in a hemiparkinsonian animal model. Significant dopamine depletion in the striatum ipsilateral to the side of infusion was observed in animals unilaterally infused with 6-hydroxydopamine (6-OHDA) in the substatia nigra. These animals displayed apomorphine-induced contralateral rotational behavior, when examined on the 16th day. Implantation of a controlled release delivery system (hydrogel obtained by mixing dextran dialdehyde cross-linked with gelatin) containing dopamine in the denervated striaturn on the 1st day or the 18th day significantly abolished the apomorphine-induced contralateral rotational behavior in these animals. The recovery was visible for about 17 days, thereafter the behavioral bias reappeared. The present results indicate that dopamine released from the polymer matrices alleviates behavioral bias in experimental parkinsonism, implying use of such technologies as an alternative method for the treatment of Parkinson's disease. This approach is useful in reducing the oral dose of drugs that are with severe systemic effects, and that develop tolerance. (C) 2007 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BVAMSTERDAMPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
 
Date 2011-09-20T12:12:27Z
2011-09-20T12:12:27Z
2007
 
Type Article
 
Identifier BEHAVIOURAL BRAIN RESEARCH
0166-4328
http://hdl.handle.net/123456789/14278
 
Language English