Supramolecular architecture in an oxovanadium(V)-schiff base complex: Synthesis, Ab initio structure determination from X-ray powder diffraction, DNA binding and cleavage activity
Metadata of CSIR Papers
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| Title |
Supramolecular architecture in an oxovanadium(V)-schiff base complex: Synthesis, Ab initio structure determination from X-ray powder diffraction, DNA binding and cleavage activity
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| Creator |
Mondal, S
Mukherjee, M Dhara, K Ghosh, S Ratha, J Banerjee, P Mukherjee, AK |
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| Subject |
Chemistry, Multidisciplinary; Crystallography; Materials Science, Multidisciplinary
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| Description |
The synthesis, spectroscopic characterization, X-ray powder structure determination, and thermal behavior of a binuclear bis(mu-oxo)-bridged vanadium(V) complex, [(VO2L2)2], L = N,N'-dimethylenediamine(o-hydroxyl acetophenon), along with its DNA binding ability and photoinduced DNA cleavage activity, have been described. The compound crystallizes in a monoclinic system with a = 7.679(3) angstrom, b = 12.020(5) angstrom, c = 13.882(6) angstrom, beta = 90.799(4)degrees, space group P2(1)/c, and Z = 2. The crystal structure has been solved from laboratory X-ray powder diffraction data using the direct space approach and refined by the Rietveld method. The dimeric complex consists of two edge-sharing vanadium octahedra with each metal center coordinated to one oxo-, one phenolate-, and two bridging-oxygen ligands, and two nitrogen donor atoms. The molecular structure reveals a two-dimensional grid of R-4(4)(24) rings in the (011) plane, which on combination with one-dimensional polymeric chains along the [100] direction, forms a novel three-dimensional supramolecular framework. Thermogravimetric analysis of the complex indicates multiple overlapping decornposition steps in the temperature range 180-800 degrees C with the end product being V2O5. The complex binds to double-stranded DNA giving a K-app value of 1.56 x 10(7) M-1 and displays DNA cleavage activity on UV (300 nm) irradiation via a mechanistic pathway involving formation of singlet oxygen as the reactive species.
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| Publisher |
AMER CHEMICAL SOCWASHINGTON1155 16TH ST, NW, WASHINGTON, DC 20036 USA
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| Date |
2011-09-20T12:12:31Z
2011-09-20T12:12:31Z 2007 |
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| Type |
Article
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| Identifier |
CRYSTAL GROWTH & DESIGN
1528-7483 http://hdl.handle.net/123456789/14305 |
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| Language |
English
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