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A two-dimensional coordination compound as a zinc ion selective luminescent probe for biological applications

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Title A two-dimensional coordination compound as a zinc ion selective luminescent probe for biological applications
 
Creator Dhara, K
Karan, S
Ratha, J
Roy, P
Chandra, G
Manassero, M
Mallik, B
Banerjee, P
 
Subject Chemistry, Multidisciplinary
 
Description A 2D coordination compound {[Cu-2(HL)(N-3)]ClO4}(infinity) (1; H3L = 2,6-bis(hydroxyethyliminoethyl)4-methyl phenol) was synthesized and characterized by single-crystal X-ray diffraction to be a polymer in the crystalline state. Each (Cu-2(HL)(N-3)](+) species is connected to its adjacent unit by a bridging alkoxide oxygen atom of the ligand to form a helical propagation along the crystallographic a axis. The adjacent helical frameworks are connected by a ligand alcoholic oxygen atom along the crystallographic b axis to produce pleated 2D sheets. In solution, 1 dissociates into [Cu-2(HL)(2) (H3L]center dot 2H(2)O (2); the monomer displays high selectivity for Zn2+ and can be used in HEPES buffer (pH 7.4) as a zinc ion selective luminescent probe for biological application. The system shows a nearly 19-fold Zn2+ -selective chelation-enhanced fluorescence response in the working buffer. Application of 2 to cultured living cells (B16FI0 mouse melanoma and A375 human melanoma) and rat hippocampal slices was also studied by fluorescence microscopy.
 
Publisher WILEY-V C H VERLAG GMBHWEINHEIMPO BOX 10 11 61, D-69451 WEINHEIM, GERMANY
 
Date 2011-09-20T12:12:32Z
2011-09-20T12:12:32Z
2007
 
Type Article
 
Identifier CHEMISTRY-AN ASIAN JOURNAL
1861-4728
http://hdl.handle.net/123456789/14314
 
Language English