Synthesis, DNA binding, and Leishmania topoisomerase inhibition activities of a novel series of anthra[1,2-d]imidazole-6,11-dione derivatives
Metadata of CSIR Papers
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| Title |
Synthesis, DNA binding, and Leishmania topoisomerase inhibition activities of a novel series of anthra[1,2-d]imidazole-6,11-dione derivatives
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| Creator |
Chaudhuri, P
Majumder, HK Bhattacharya, S |
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| Subject |
Chemistry, Medicinal
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| Description |
Nine novel anthra[1,2-d]imidazole-6,11-diones, differing in their side chain, were synthesized. UV-vis spectroscopy and viscometric titrations of these molecules with duplex DNA were used to assess their binding with DNA. Five of the nine compounds showed high inhibition activity against topoisomerase I of Leishmania donovani, with the one bearing the tetrazole side chain exhibiting an IC50 - 1 mu M. The inhibition activities were not related with their DNA binding affinity and depended on the nature of the side chain.
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| Publisher |
AMER CHEMICAL SOCWASHINGTON1155 16TH ST, NW, WASHINGTON, DC 20036 USA
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| Date |
2011-09-20T12:12:37Z
2011-09-20T12:12:37Z 2007 |
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| Type |
Article
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| Identifier |
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 http://hdl.handle.net/123456789/14347 |
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| Language |
English
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