Depolarization and cardiolipin depletion in aged rat brain mitochondria: Relationship with oxidative stress and electron transport chain activity
Metadata of CSIR Papers
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| Title |
Depolarization and cardiolipin depletion in aged rat brain mitochondria: Relationship with oxidative stress and electron transport chain activity
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| Creator |
Sen, T
Sen, N Jana, S Khan, FH Chatterjee, U Chakrabarti, S |
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| Subject |
Biochemistry & Molecular Biology; Neurosciences
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| Description |
A noticeable loss of cardiolipin, a significant accumulation of fluorescent products of lipid peroxidation and an increased ability to produce reactive oxygen species in vitro are characteristics of aged rat brain mitochondria, as has been demonstrated in this study. In contrast mitochondrial electron transport chain activity is Dot significantly compromised except a marginal decline in complex IV activity in aged rat brain. On the other hand, a striking loss of mitochondrial membrane potential occurs in brain mitochondria during aging, which may be attributed to peroxidative membrane damage in this condition. Such mitochondrial dysfunctions as reported here may lead to uncoupling of oxidative pbosphorylation, ATP depletion and activation of apoptotic cascade in aged rat brain. (c) 2007 Elsevier Ltd. All rights reserved.
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| Publisher |
PERGAMON-ELSEVIER SCIENCE LTDOXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
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| Date |
2011-09-20T12:12:37Z
2011-09-20T12:12:37Z 2007 |
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| Type |
Article
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| Identifier |
NEUROCHEMISTRY INTERNATIONAL
0197-0186 http://hdl.handle.net/123456789/14348 |
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| Language |
English
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