An Electronic Analog of Synthetic Genetic Networks
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
An Electronic Analog of Synthetic Genetic Networks
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| Creator |
Hellen, Edward H
Volkov, Evgenii Kurths, Jurgen Dana, Syamal Kumar |
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| Subject |
Nonlinear Dynamics
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| Description |
An electronic analog of a synthetic genetic network known as the repressilator is proposed. The repressilator is a synthetic
biological clock consisting of a cyclic inhibitory network of three negative regulatory genes which produces oscillations in
the expressed protein concentrations. Compared to previous circuit analogs of the repressilator, the circuit here takes into
account more accurately the kinetics of gene expression, inhibition, and protein degradation. A good agreement between
circuit measurements and numerical prediction is observed. The circuit allows for easy control of the kinetic parameters
thereby aiding investigations of large varieties of potential dynamics.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/8/1/iicb6.pdf
Hellen, Edward H and Volkov, Evgenii and Kurths, Jurgen and Dana, Syamal Kumar (2011) An Electronic Analog of Synthetic Genetic Networks. PLoS One, 6 (8). p. 323286. |
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| Relation |
http://dx.doi.org/10.1371/journal.pone.0023286
http://www.eprints.iicb.res.in/8/ |
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