DNA topoisomerases of leishmania: modulation of functional activity and drug induced cell killing of the parasite
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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Title |
DNA topoisomerases of leishmania:
modulation of functional activity and drug
induced cell killing of the parasite
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Creator |
Sen Gupta, Souvik
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Subject |
Infectious Diseases and Immunology
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Description |
There are a plethora of problems accompanying various transactions involving
DNA and all are ultimately rooted to the bihelical geometry of this
master molecule. DNA topoisomerases are a family of enzymes which provide
some of the necessary tools in various manipulations of the thread like double
stranded DNA. The two strands of the DNA helix must separate either temporarily
as in transcription or recombination or permanently as in replication.
DNA topoisomerases accomplish their feats by the simple and elegant chemistry
of transesterification.
DNA topoisomerases are a family of DNA processing enzymes that use
DNA strand scission, manipulation, and rejoining activities to directly modulate
DNA topology. These actions provide a powerful means to effect changes in
DNA supercoiling levels, and allow some topoisomerases to both unknot and
decatenate chromosomes. They are truly wonders, as in their presence, DNA
strands can pass each other as if the physical boundaries between them have
disappeared (Wang, 1985). They single handedly solve various topological problems
for the effective propagation of the genetic material. They solve the topological
problems associated with DNA replication, transcription,
recombination, and chromatin remodeling by introducing temporary single- or
double-strand breaks in the DNA (Champoux, 2001 and Liu, 1994). Topoisomerases
are now known to be necessary for the survival of cellular organisms
and many viruses and are rich clinical targets for anticancer, antiparasitic and antimicrobial
treatments.
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Date |
2011
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Type |
Thesis
NonPeerReviewed |
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Format |
application/pdf
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Identifier |
http://www.eprints.iicb.res.in/14/1/SOUVIK_THESIS_2011.pdf
Sen Gupta, Souvik (2011) DNA topoisomerases of leishmania: modulation of functional activity and drug induced cell killing of the parasite. PhD thesis, Jadavpur University. |
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Relation |
http://www.eprints.iicb.res.in/14/
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