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Ascorbate Peroxidase from Leishmania major Controls the Virulence of Infective Stage of Promastigotes by Regulating Oxidative Stress

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Ascorbate Peroxidase from Leishmania major Controls the Virulence of Infective Stage of Promastigotes by Regulating Oxidative Stress
 
Creator Pal, Swati
Dolai, Subhankar
Yadav, Rajesh K
Adak, Subrata
 
Subject Structural Biology & Bioinformatics
 
Description Peroxidase represents a heterogeneous group of distinct enzyme family that plays extremely diverse biological functions. Ascorbate peroxidase from Leishmania major (LmAPX) has been shown to be central to the redox defense system of Leishmania. To investigate further its exact physiological role in Leishmania, we attempted to create LmAPX -knockout mutants by gene replacement in L. major strains.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/18/1/PLOS_ONE_5(6)_Article_Number_e11271;2010[65].pdf
Pal, Swati and Dolai, Subhankar and Yadav, Rajesh K and Adak, Subrata (2010) Ascorbate Peroxidase from Leishmania major Controls the Virulence of Infective Stage of Promastigotes by Regulating Oxidative Stress. PLoS One, 5 (6). e11271.
 
Relation http://dx.doi.org/10.1371/journal.pone.0011271
http://www.eprints.iicb.res.in/18/