Molecular Recognition of poly(A) Targeting by Protoberberine Alkaloids: in Vitro Biophysical Studies and Biological Perspectives
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Molecular Recognition of poly(A) Targeting by Protoberberine Alkaloids:
in Vitro Biophysical Studies and Biological Perspectives
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| Creator |
Giri, Prabal
Kumar, G Suresh |
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| Subject |
Chemistry
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| Description |
The use of small molecules to specifically control important cellular functions through binding to
nucleic acids is an area of major current interest at the interface of chemical biology and
medicinal chemistry. The polyadenylic acid [poly(A)] tail of mRNA has been recently established
as a potential drug target due to its significant role in the initiation of translation, maturation and
stability of mRNA as well as in the production of alternate proteins in eukaryotic cells. Very
recently some small molecule alkaloids of the isoquinoline group have been found to bind poly(A)
with remarkably high affinity leading to self-structure formation. Plant alkaloids are small
molecules known to have important traditional roles in medicinal chemistry due to their extensive
biological activity. Especially, noteworthy are the protoberberine alkaloids that are widely
distributed in several botanical families exhibiting myriad therapeutic applications. This review
focuses on the structural and biological significance of poly(A) and interaction of protoberberine
alkaloids with this RNA structure for the development of new small molecule alkaloids targeted
to poly(A) structures as futuristic therapeutic agents.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/44/1/MOLECULAR_BIOSYSTEMS__6_1);2010[133].pdf
Giri, Prabal and Kumar, G Suresh (2010) Molecular Recognition of poly(A) Targeting by Protoberberine Alkaloids: in Vitro Biophysical Studies and Biological Perspectives. Molecular Biosystems, 6. pp. 81-88. |
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| Relation |
http://dx.doi.org/10.1039/b910706a
http://www.eprints.iicb.res.in/44/ |
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