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A Rapid and Facile Method for the General Synthesis of 3-Aryl Substituted 4,5,6,7-Tetrahydro[1,2,3]Triazolo[1,5-a]Pyrazines and their Ring Fused analogues

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title A Rapid and Facile Method for the General Synthesis of 3-Aryl Substituted 4,5,6,7-Tetrahydro[1,2,3]Triazolo[1,5-a]Pyrazines and their Ring Fused analogues
 
Creator Chowdhury, Chinmay
Mukherjee, Sanjukta
Chakraborty, Biswajit
Achari, Basudeb
 
Subject Chemistry
 
Description We report a general and facile method that provides rapid entry into 3-aryl substituted 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazines and their ring fused analogues in one-pot under palladium–copper catalysis. The methodology utilises simple and easily available substrates of broad range. The applicability of this reaction for the synthesis of optically active products has been demonstrated. A plausible reaction mechanism has also been proposed.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/66/1/ORGANIC_%26_BIOMOLECULAR_CHEMISTRY%2C9(16)%2C_5856%2D5862%2C2011[97].pdf
Chowdhury, Chinmay and Mukherjee, Sanjukta and Chakraborty, Biswajit and Achari, Basudeb (2011) A Rapid and Facile Method for the General Synthesis of 3-Aryl Substituted 4,5,6,7-Tetrahydro[1,2,3]Triazolo[1,5-a]Pyrazines and their Ring Fused analogues. Organic & Biomolecular Chemistry, 9 (16). pp. 5856-5862.
 
Relation http://dx.doi.org/10.1039/c1ob05255a
http://www.eprints.iicb.res.in/66/