Binding of 9-O-(u-amino) alkyl ether analogues of the plant alkaloid berberine to poly(A): insights into self-structure induction
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Binding of 9-O-(u-amino) alkyl ether analogues of the plant alkaloid
berberine to poly(A): insights into self-structure induction
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| Creator |
Islam, Md. Maidul
Basu, Anirban Gopinatha, Suresh Kumar |
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| Subject |
Chemistry
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| Description |
Berberine, the plant alkaloid, was recently shown to induce self-structure in poly(A) by a unique
dilution technique. The interaction of berberine and five 9-(u-amino) alkyl ether analogues with
polyadenylic acid [poly (A)] has been studied to understand the role of an additional anchoring module
in the formation and/or amplification of self-structure in poly(A). The binding was characterized by
absorption and fluorescence titration, Job’s plot and isothermal titration calorimetry. All the molecules
bound cooperatively to poly(A). Self-structure formation was confirmed by circular dichroic melting,
optical melting, and dilution experiments. Energetics of the interaction revealed that as the alkyl chain
length increased, the binding was more entropy dominated. The results showed that berberine and all
the analogues induced self-structure formation in poly(A). The length of the alkyl chain had
a significant influence on the ease of formation of self-structure. New insights in terms of structural and
thermodynamic aspects into self-structure formation in poly(A) by berberine analogues are revealed
from these studies.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/108/1/MEDCHEMCOMM%2CVolume_2%2C_Issue_7%2C631%2D637%2C2011[25].pdf
Islam, Md. Maidul and Basu, Anirban and Gopinatha, Suresh Kumar (2011) Binding of 9-O-(u-amino) alkyl ether analogues of the plant alkaloid berberine to poly(A): insights into self-structure induction. Med. Chem. Commun., 2 (7). pp. 631-637. |
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| Relation |
http://dx.doi.org/10.1039/C0MD00209G
http://www.eprints.iicb.res.in/108/ |
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