Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice�
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates
from India and during Infections in Mice�
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| Creator |
De, Ronita
Kundu, Parag Swarnakar, Snehasikta Ramamurthy, T Chowdhury, Abhijit Nair, G. Balakrish Mukhopadhyay, Asish K |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
Treatment failure is a major cause of concern for the Helicobacter pylori-related gastroduodenal diseases like
gastritis, peptic ulcer, and gastric cancer. Curcumin, diferuloylmethane from turmeric, has recently been
shown to arrest H. pylori growth. The antibacterial activity of curcumin against 65 clinical isolates of H. pylori
in vitro and during protection against H. pylori infection in vivo was examined. The MIC of curcumin ranges
from 5 �g/ml to 50 �g/ml, showing its effectiveness in inhibiting H. pylori growth in vitro irrespective of the
genetic makeup of the strains. The nucleotide sequences of the aroE genes, encoding shikimate dehydrogenase,
against which curcumin seems to act as a noncompetitive inhibitor, from H. pylori strains presenting differential
curcumin MICs showed that curcumin-mediated growth inhibition of Indian H. pylori strains may not
be always dependent on the shikimate pathway. The antimicrobial effect of curcumin in H. pylori-infected
C57BL/6 mice and its efficacy in reducing the gastric damage due to infection were examined histologically.
Curcumin showed immense therapeutic potential against H. pylori infection as it was highly effective in
eradication of H. pylori from infected mice as well as in restoration of H. pylori-induced gastric damage. This
study provides novel insights into the therapeutic effect of curcumin against H. pylori infection, suggesting its
potential as an alternative therapy, and opens the way for further studies on identification of novel antimicrobial
targets of curcumin.
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| Publisher |
American Society for Microbiology
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/129/1/ANTIMICROBIAL_AGENTS_AND_CHEMOTHERAPY%2C53(_4)%2C1592%2D1597%2C__2009[83].pdf
De, Ronita and Kundu, Parag and Swarnakar, Snehasikta and Ramamurthy, T and Chowdhury, Abhijit and Nair, G. Balakrish and Mukhopadhyay, Asish K (2009) Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice�. Antimicrobial Agents and Chemotherapy, 53 (4). pp. 1492-1597. |
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| Relation |
http://dx.doi.org/10.1128/AAC.01242-08
http://www.eprints.iicb.res.in/129/ |
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