Association of Specific Haplotype of TNFα with Helicobacter Pylori-Mediated Duodenal Ulcer in Eastern Indian Population
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Association of Specific Haplotype of TNFα with Helicobacter
Pylori-Mediated Duodenal Ulcer in Eastern Indian Population
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| Creator |
Chakravorty, Meenakshi
Datta De, Dipanjana Choudhury, Abhijit Satra, Amal Roychoudhury, Susanta |
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| Subject |
Molecular & Human Genetics
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| Description |
In the present study, we investigated the association between cytokine gene polymorphisms and Helicobacter pylori-
mediated gastroduodenal ulcer in eastern Indian population.
The analysis of promoter polymorphisms of TNF-α,
IL6 and IL8 revealed no association with H. pylori-mediated
duodenal ulcer at the genotype level. However, TNF-α haplotype GCAT, was present at a significantly higher frequency in H. pylori infected individuals with duodenal ulcers, than in those infected individuals without ulceration (odds ratio (OR) = 8.07, with 95% confidence intervals (95%CI) = 1.26–50.4, P < 0.05). We also observed difference of expression of these cytokine genes between H. pylori infected symptomatic and asymptomatic individuals. However, no correlation was observed between the expression of these cytokine genes and the polymorphic status of the individuals.
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| Date |
2008
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/169/1/JOURNAL_OF_GENETICS%2C_87(3)%2C_299%2D304%2C2008[4].pdf
Chakravorty, Meenakshi and Datta De, Dipanjana and Choudhury, Abhijit and Satra, Amal and Roychoudhury, Susanta (2008) Association of Specific Haplotype of TNFα with Helicobacter Pylori-Mediated Duodenal Ulcer in Eastern Indian Population. Journal of Genetics, 87 (3). pp. 299-304. |
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| Relation |
http://dx.doi.org/10.1007/s12041-008-0048-9
http://www.eprints.iicb.res.in/169/ |
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