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UDP-Gal: N-acetylglucosamine β 1–4 galactosyltransferase expressing live attenuated parasites as vaccine for visceral leishmaniasis

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title UDP-Gal: N-acetylglucosamine β 1–4 galactosyltransferase expressing live attenuated parasites as vaccine for visceral leishmaniasis
 
Creator Bhaumik, Siddhartha Kumar
Singh, Manoj Kumar
Karmakar, Subir
De, Tripti
 
Subject Infectious Diseases and Immunology
 
Description As compared to cutaneous leishmaniasis, vaccination against visceral leishmaniasis (VL) has received limited attention. In this study, we demonstrate for the first time that an UDP-Galactose: N-acetylglucosamine β 1–4 galactosyltransferase (GenBank Accession No. EF159943) expressing attenuated LD clonal population (A-LD) is able to confer protection against the experimental challenge with the virulent LD AG83 parasite. A-LD was also effective in established leishmania infection. The vaccinated animals showed both cell mediated (in vitro T-cell proliferation, and DTH response) and humoral responses (Th1 type). These results demonstrate the potential of the attenuated clones as an immunotherapeutic and immunoprophylactic agent against visceral leishmaniasis.
 
Publisher Kluwer
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/171/1/GLYCOCONJUGATE_JOURNAL%2C_26(6)%2C_663%2D673%2C2009[40].pdf
Bhaumik, Siddhartha Kumar and Singh, Manoj Kumar and Karmakar, Subir and De, Tripti (2009) UDP-Gal: N-acetylglucosamine β 1–4 galactosyltransferase expressing live attenuated parasites as vaccine for visceral leishmaniasis. Glycoconjugate Journal, 26. pp. 663-673.
 
Relation http://dx.doi.org/10.1007/s10719-008-9212-y
http://www.eprints.iicb.res.in/171/