An Insight on the Neuropharmacological Activity of Telescopium Telescopium – A Mollusc From the Sunderban Mangrove
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
An Insight on the Neuropharmacological
Activity of Telescopium Telescopium – A Mollusc
From the Sunderban Mangrove
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| Creator |
Samanta, S K
Manisenthil Kumara, K T Roy, Amrita Karmakar, S Lahiri, Sagar Palit, G Vedasiromoni, J R Sen, T |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
The present study was carried out to evaluate the biological properties of the tissue
extract of a marine snail Telescopium telescopium, collected from the coastal regions of
West Bengal India. On extensive pharmacological screening, it was found that the
biological extract of T. telescopium (TTE) produced significant central nervous system
(CNS)-depressant activity as observed from the reduced spontaneous motility,
potentiation of pentobarbitone induced sleeping time, hypothermia and respiratory
depression with transient apnoea. The extract significantly decreased both residual
curiosity and also muscle coordination. The fraction, obtained following saturation
with 60–80% ammonium sulphate (80S), was also found to demonstrate predominant
CNS-depressant activity. It was observed that both TTE and the 80S fraction
significantly altered the brain noradrenaline and homovanillic acid levels without
affecting the brain gamma amino butyric acid (GABA) concentration. Based on the
present observations, it can be suggested that the CNS-depressant effects produced by
TTE and 80S could be attributable to modified catecholamine metabolism in the
brain.
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| Date |
2008
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/176/1/FUNDAMENTAL_%26_CLINICAL_PHARMACOLOGY%2C22(_6)%2C_683%2D691%2C_2008[11].pdf
Samanta, S K and Manisenthil Kumara, K T and Roy, Amrita and Karmakar, S and Lahiri, Sagar and Palit, G and Vedasiromoni, J R and Sen, T (2008) An Insight on the Neuropharmacological Activity of Telescopium Telescopium – A Mollusc From the Sunderban Mangrove. Fundamental & Clinical Pharmacology, 22 (6). pp. 683-691. |
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| Relation |
htp://dx.doi.org/10.1111/j.1472-8206.2008.00631.x
http://www.eprints.iicb.res.in/176/ |
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