Taurine Fails to Protect Against 1-methyl-4-phenyl-1,2,3,6- Tetrahydropyridine-Induced Striatal Dopamine Depletion in Mice
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive InfoField | Value | |
Title |
Taurine Fails to Protect Against 1-methyl-4-phenyl-1,2,3,6-
Tetrahydropyridine-Induced Striatal Dopamine Depletion in Mice
|
|
Creator |
Navneet, A K
Appukuttan, T A Pandey, M Mohanakumar, K P |
|
Subject |
Cell Biology & Physiology
|
|
Description |
The potent parkinsonian neurotoxin, 1-methyl-4-phenyl-
1,2,3,6-tetrahydropyridine (MPTP) through its oxidized
metabolite, 1-methyl-4-phenylpyridinium (MPPþ) causes
lesion specifically to the dopaminergic system of the substantia nigra pars compacta (SNpc) of the brain (Burns
et al., 1983). This ability of MPTP and MPPþ has been
exploited to develop animal models for Parkinson’s disease
(PD). MPTP crosses the blood–brain barrier, gets converted
to its neurotoxically active metabolite MPPþ by
monoamine oxidase-B in astrocytes and is selectively taken
up into dopaminergic neurons by dopamine (DA) transporters
(Javitch et al., 1985; Ransom et al., 1987), where
it is sequestered into the mitochondria (Ramsay and Singer,
1986). MPPþ causes mitochondrial complex I inhibition,
leading to an out surge of free radical species as the lethal process in the neuronal death (Tieu et al., 2003).
|
|
Date |
2008
|
|
Type |
Article
PeerReviewed |
|
Format |
application/pdf
|
|
Identifier |
http://www.eprints.iicb.res.in/179/1/AMINO_ACIDS%2C_35(2)%2C_457%2D461%2C2008[49].pdf
Navneet, A K and Appukuttan, T A and Pandey, M and Mohanakumar, K P (2008) Taurine Fails to Protect Against 1-methyl-4-phenyl-1,2,3,6- Tetrahydropyridine-Induced Striatal Dopamine Depletion in Mice. Amino Acids, 35 (2). pp. 457-461. |
|
Relation |
http://dx.doi.org/10.1007/s00726-007-0571-7
http://www.eprints.iicb.res.in/179/ |
|