Stearylamine-Bearing Cationic Liposomes Kill Leishmania parasites through Surface Exposed Negatively Charged Phosphatidylserine
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Stearylamine-Bearing Cationic Liposomes Kill Leishmania parasites through Surface Exposed Negatively Charged Phosphatidylserine
|
|
| Creator |
Banerjee, Antara
Roychoudhury, Jayeeta Ali, Nahid |
|
| Subject |
Infectious Diseases and Immunology
|
|
| Description |
Leishmania parasites are the causative agents for cutaneous and visceral leishmaniasis (VL) with �2 million cases annually and a prevalence rate of 12 million, respectively. VL, principally caused by Leishmania donovani, is fatal if left untreated.1 Pentavalent antimonials, though toxic, remain the first-line drugs for leishmaniasis. Emergence of drug resistance has pushed in second-line drugs such as amphotericin B and pentamidine, which cause toxic side effects.2–4 Miltefosine, the most recent oral drug for VL, is potentially teratogenic.2 Moreover, clinical
trials have identified occasional gastrointestinal toxicity that requires treatment withdrawal
|
|
| Date |
2008
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/238/1/JOURNAL_OF_ANTIMICROBIAL_CHEMOTHERAPY%2C61(1)%2C103%2D110%2C2008[145].pdf
Banerjee, Antara and Roychoudhury, Jayeeta and Ali, Nahid (2008) Stearylamine-Bearing Cationic Liposomes Kill Leishmania parasites through Surface Exposed Negatively Charged Phosphatidylserine. Journal of Antimicrobial Chemotherapy, 61 (1). pp. 103-110. |
|
| Relation |
http://dx.doi.org/10.1093/jac/dkm396
http://www.eprints.iicb.res.in/238/ |
|