Excess of Glucocorticoid Induces Cardiac Dysfunction via Activating Angiotensin II Pathway
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Excess of Glucocorticoid Induces Cardiac
Dysfunction via Activating Angiotensin II Pathway
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| Creator |
Ghose Roy, Sreerupa
De, Priyanka Mukherjee, Debasri Chander, Vivek Konar, Aditya Bandyopadhyay, Debasish Bandyopadhyay, Arun |
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| Subject |
Cell Biology & Physiology
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| Description |
Background: Glucocorticoid is widely used as an
anti-inflammatory drug in various diseases however
excess of it often causes cardiovascular
complications. The present study was undertaken to
understand the molecular mechanism of
glucocorticoid-induced cardiac dysfunction. Methods:
Rats were treated daily with synthetic glucocorticoid,
dexamethasone with or without mifepristone or
losartan up to 15 days. Hemodynamic parameters
were measured by PV-loop method using Millar’s
instrument. Cardiac remodelling, fibrosis and oxidative
stress were monitored after 15 days. Results: The
systolic blood pressure was increased whereas the
heart beat and cardiac output (n=6) were decreased
by dexamethasone. Dexamethasone caused increase
in the heart weight to body weight ratio (P<0.001,
n=20), increased level of mRNA of atrial natriuretic
peptide and an increased deposition of collagens in
the extracellular matrix of the left ventricle which were
inhibited by both mifepristone and losartan. The rate of oxygen consumption was decreased in association
with increased levels of hypoxia inducible factor 1
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| Publisher |
Karger
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/258/1/CELLULAR_PHYSIOLOGY_AND_BIOCHEMISTRY%2C_24(1%2D2)%2C1%2D10%2C2009[131].pdf
Ghose Roy, Sreerupa and De, Priyanka and Mukherjee, Debasri and Chander, Vivek and Konar, Aditya and Bandyopadhyay, Debasish and Bandyopadhyay, Arun (2009) Excess of Glucocorticoid Induces Cardiac Dysfunction via Activating Angiotensin II Pathway. Cellular Physiology and Biochemistry, 24 (1-2). 01-10. |
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| Relation |
http://dx.doi.org/10.1159/000227803
http://www.eprints.iicb.res.in/258/ |
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