Supramolecular Architecture in an Oxovanadium(V)-Schiff Base Complex: Synthesis, Ab initio Structure Determination from X-ray Powder Diffraction, DNA Binding and Cleavage Activity
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Supramolecular Architecture in an Oxovanadium(V)-Schiff Base
Complex: Synthesis, Ab initio Structure Determination from X-ray
Powder Diffraction, DNA Binding and Cleavage Activity
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| Creator |
Mondal, Swastik
Mukherjee, Monika Dhara, Koushik Ghosh, Soumen Ratha, Jagnyeswar Banerjee, Pradyot Mukherjee, Alok K. |
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| Subject |
Chemistry
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| Description |
The synthesis, spectroscopic characterization, X-ray powder structure determination, and thermal behavior of a binuclear
bis(í-oxo)-bridged vanadium(V) complex, [(VO2L)2], L ) N,N¢-dimethylenediamine(o-hydroxyl acetophenon), along with its DNA
binding ability and photoinduced DNA cleavage activity, have been described. The compound crystallizes in a monoclinic system
with a ) 7.679(3) Å, b ) 12.020(5) Å, c ) 13.882(6) Å, â ) 90.799(4)°, space group P21/c, and Z ) 2. The crystal structure has
been solved from laboratory X-ray powder diffraction data using the direct space approach and refined by the Rietveld method. The
dimeric complex consists of two edge-sharing vanadium octahedra with each metal center coordinated to one oxo-, one phenolate-,
and two bridging-oxygen ligands, and two nitrogen donor atoms. The molecular structure reveals a two-dimensional grid of R4 4 (24)
rings in the (011) plane, which on combination with one-dimensional polymeric chains along the [100] direction, forms a novel
three-dimensional supramolecular framework. Thermogravimetric analysis of the complex indicates multiple overlapping decomposition
steps in the temperature range 180-800 °C with the end product being V2O5. The complex binds to double-stranded DNA giving
a Kapp value of 1.56 � 107 M-1 and displays DNA cleavage activity on UV (300 nm) irradiation via a mechanistic pathway involving
formation of singlet oxygen as the reactive species.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/264/1/CRYSTAL_GROWTH_%26_DESIGN%2C7(9)%2C1716%2D1721%2C2007[36].pdf
Mondal, Swastik and Mukherjee, Monika and Dhara, Koushik and Ghosh, Soumen and Ratha, Jagnyeswar and Banerjee, Pradyot and Mukherjee, Alok K. (2007) Supramolecular Architecture in an Oxovanadium(V)-Schiff Base Complex: Synthesis, Ab initio Structure Determination from X-ray Powder Diffraction, DNA Binding and Cleavage Activity. Crystal Growth & Design, 7 (9). pp. 1716-1721. |
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| Relation |
http://dx.doi.org/10.1021/cg060753i CCC: $37.00
http://www.eprints.iicb.res.in/264/ |
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