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Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis
 
Creator Palit, Partha
Ali, Nahid
 
Subject Infectious Diseases and Immunology
 
Description Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/278/1/ANTIMICROBIAL_AGENTS_AND_CHEMOTHERAPY%2C52_(1)_374%2D377%2C_2008_[147].pdf
Palit, Partha and Ali, Nahid (2008) Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis. Antimicrobial Agents And Chemotherapy, 52 (1). pp. 374-377.
 
Relation http://dx.doi.org/10.1128/AAC.00522-07
http://www.eprints.iicb.res.in/278/