Identi¢cation ofa newRTX-like Gene Cluster InVibrio Cholerae
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Identi¢cation ofa newRTX-like Gene Cluster InVibrio Cholerae
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| Creator |
Chatterjee, Raghunath
Nag, Sanjay Chaudhuri, Keya |
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| Subject |
Molecular & Human Genetics
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| Description |
A gene cluster containing two genes in tandem has been identified in Vibrio cholerae ElTor N16961. Each has more than one cadherin domain and is homologous to the RTX toxin family and was common in various V. cholerae strains. Insertional mutagenesis demonstrated that each gene has a role in Hep-2 cell rounding, hemolytic activity towards human and sheep RBCs and biofilm formation. The mutants showed reduced adherence to intestinal epithelial cells as
well as reduction of in vivo colonization in suckling mice. These two genes thus code for RTX-like toxins in V. cholerae and are associated with the pathogenecity of
this organism.
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| Date |
2008
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/284/1/FEMS_MICROBIOLOGY_LETTERS%2C284(_2)%2C165%2D171%2C2008[58].pdf
Chatterjee, Raghunath and Nag, Sanjay and Chaudhuri, Keya (2008) Identi¢cation ofa newRTX-like Gene Cluster InVibrio Cholerae. FEMS Microbiol Letters, 284 (2). pp. 165-171. |
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| Relation |
http://dx.doi.org/10.1111/j.1574-6968.2008.01199.x
http://www.eprints.iicb.res.in/284/ |
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