Evidence for Heterogeneous Nuclear Ribonucleoprotein K Overexpression in Oral Squamous Cell Carcinoma
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Evidence for Heterogeneous Nuclear Ribonucleoprotein K
Overexpression in Oral Squamous Cell Carcinoma
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| Creator |
Roychoudhury, P
Chaudhuri, Keya |
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| Subject |
Molecular & Human Genetics
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| Description |
The recent paper of Carpenter et al (2006b) in your journal
identified hnRNP K as being overexpressed in colorectal cancer by proteomics, which has been confirmed by immunohistochemistry and tissue microarray analysis. Their study also showed that hnRNP K had an aberrant subcellular localisation in cancer cells. Although there were previous reports by Moumen et al (2005), suggesting that, in response to DNA damage, p53 inhibits hnRNP K ubiquitin-dependent proteasomal degradation, the study by
Carpenter et al (2006a) could not, however, find any correlation between the expression of hnRNP K and p53 in colorectal cancer cells. We note the above observations with interest, as hnRNP K has a role in tumorigenesis and its expression has been found to be upregulated in several other cancers, including those of lungs and
liver (Carpenter et al, 2006a).
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/304/1/BRITISH_JOURNAL_OF_CANCER%2C_97(4)%2C574%2D575[50].pdf
Roychoudhury, P and Chaudhuri, Keya (2007) Evidence for Heterogeneous Nuclear Ribonucleoprotein K Overexpression in Oral Squamous Cell Carcinoma. British Journal of Cancer, 97. pp. 574-575. |
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| Relation |
http://dx.doi.org/10.1038/sj.bjc.6603911
http://www.eprints.iicb.res.in/304/ |
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