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Granulocyte–Macrophage Colony-Stimulating Factor Drives Monocytes to CD14low CD83+ DCSIGN– Interleukin-10-producing Myeloid Cells with Differential Effects on T-cell Subsets

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Granulocyte–Macrophage Colony-Stimulating Factor Drives Monocytes to CD14low CD83+ DCSIGN– Interleukin-10-producing Myeloid Cells with Differential Effects on T-cell Subsets
 
Creator Ganguly, Dipyaman
Paul, Kausik
Bagchi, Jayashree
Rakshit, Srabanti
Mandal, Labanya
Bandyopadhyay, Gautam
Bandyopadhyay, Santu
 
Subject Infectious Diseases and Immunology
 
Description Granulocyte–macrophage colony-stimulating factor (GMCSF), a 23 000 molecular weight (MW) heavily glycosylated cytokine, is known to have growth-promoting activities on haematopoietic cell lineages. This cytokine was identified in lung-tissue-conditioned medium from lipopolysaccharide-injected mice, as a component showing stimulatory activity on the proliferation of mouse bone marrow cells in vitro, generating colonies of both granulocytes and macrophages.1 GM-CSF is known to stimulate multipotent progenitors depending on its concentration. 2 GM-CSF, in both humans and mice, was cloned from a complementary DNA library of activated T lymphocytes.3,4 Various subsets of T lymphocytes have been found to produce GM-CSF on activation, although its direct effect on the T lymphocytes is not yet clear.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/307/1/IMMUNOLOGY%2C_121(_4)%2C_499%2D507[59].pdf
Ganguly, Dipyaman and Paul, Kausik and Bagchi, Jayashree and Rakshit, Srabanti and Mandal, Labanya and Bandyopadhyay, Gautam and Bandyopadhyay, Santu (2007) Granulocyte–Macrophage Colony-Stimulating Factor Drives Monocytes to CD14low CD83+ DCSIGN– Interleukin-10-producing Myeloid Cells with Differential Effects on T-cell Subsets. Immunology, 121 (4). pp. 499-507.
 
Relation http://dx.doi.org/10.1111/j.1365-2567.2007.02596.x
http://www.eprints.iicb.res.in/307/