Risk Assessment of p53 Genotypes and Haplotypes in Tobacco-Associated Leukoplakia and oral Cancer Patients from Eastern India.
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Risk Assessment of p53 Genotypes and Haplotypes in Tobacco-Associated Leukoplakia and oral Cancer Patients from Eastern India.
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| Creator |
Mitra, Sayan
Sikdar, Nilabja Misra, Chaitali Gupta, Shalini Paul, Ranjan Rashmi Roy, Bidyut Panda, Chinmay Kumar Roychoudhury, Susanta |
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| Subject |
Molecular & Human Genetics
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| Description |
The role of 3 p53 polymorphisms (16 bp duplication at intron 3, codon 72 Arg/Pro and intron 6 NciI RFLP at np 13494) as potential markers for indicating cancer risk remains inconclusive. In our case-control study consisting of 197 leukoplakia and 310 oral squamous cell carcinoma (SCC) patients and 348 controls, genotype frequencies at these 3 p53 loci were determined by PCRRFLP method and analyzed by multiple logistic regression to determine the risks of the diseases. The 2/2 genotype at codon 72
of p53 was at risk for developing leukoplakia (OR 5 1.6, 95% CI 1.1–2.3), whereas the combination of 1/2 and 2/2 genotypes at
intron 3 and 1/1 and 1/2 genotypes at intron 6 conferred a protective
effect against leukoplakia and oral SCC development, respectively
(OR 5 0.5, 95% CI 0.4–0.8 and OR 5 0.6, 95% CI 0.5–0.9,
respectively). When subjects were stratified according to specific
tobacco habit, the risk/protection estimates improved significantly
in some cases. Specifically, the exclusive smokers with p53 codon
72 2/2 genotype showed a higher risk of developing leukoplakia
(OR 5 2.7, 95% CI 1.2–6.3). Furthermore, a particular p53 haplotype
1-2-2 was at risk for both tobacco-associated leukoplakia and
oral SCC (OR 5 1.5, 95% CI 1.1–1.9 and OR 5 1.3, 95% CI 1.1–
1.7, respectively). Our results show that both specific p53 genotype
and haplotype can indicate risk of tobacco-associated leukoplakia,
but risk of development of tobacco-associated oral SCC can be
predicted by specific p53 haplotype only.
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| Date |
2005
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/320/1/INTERNATIONAL_JOURNAL_OF_CANCER_117(_5)786%2D793_2005[3].pdf
Mitra, Sayan and Sikdar, Nilabja and Misra, Chaitali and Gupta, Shalini and Paul, Ranjan Rashmi and Roy, Bidyut and Panda, Chinmay Kumar and Roychoudhury, Susanta (2005) Risk Assessment of p53 Genotypes and Haplotypes in Tobacco-Associated Leukoplakia and oral Cancer Patients from Eastern India. International Journal of Cancer, 117 (5). pp. 786-793. |
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| Relation |
htpp://dx.doi.org/10.1002/ijc.21263
http://www.eprints.iicb.res.in/320/ |
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