Reactivity of polyaminocarboxylatoruthenium(III) complexes with serine and their protease inhibition
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Reactivity of polyaminocarboxylatoruthenium(III)
complexes with serine and their protease inhibition
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| Creator |
Chatterjee, Debabrata
Sengupta, Ayon Mitra , Anannya Basak, Susan Bhattacharyya, Reema Bhattacharyya, Debasish |
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| Subject |
Structural Biology & Bioinformatics
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| Description |
Reaction of [Ru(edta)(H2O)]� (edta4�¼ethylenediaminetetraacetate), [Ru(pdta)(H2O)]�
(pdta4�¼propylenediaminetetraacetate) and [Ru(hedtra)(H2O)] (hedtra3�¼N-hydroxyethylethylenediaminetriacetate)
with S-serine (Ser) was studied spectrophotometrically and
kinetically. Serine protease inhibition studies were performed with the three complexes
using the serine protease enzymes chymotrypsin and subtilisin with azoalbumin as
substrate. Results are discussed in terms of the reactivity of the Ru-pac (pac¼polyaminopolycarboxylates)
complexes with serine. The order of protease inhibition efficacy of the Ru-pac
complexes is [Ru(pdta)(H2O)]�>[Ru(edta)(H2O)]��[Ru(hedtra)(H2O)], in good agreement
with the observed reactivity of Ru-pac complexes with serine.
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| Publisher |
Taylor & Francis
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| Date |
2005
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/325/1/JOURNAL_OF_COORDINATION_CHEMISTRY_58(18)1703%2D1711;2005[2].pdf
Chatterjee, Debabrata and Sengupta, Ayon and Mitra , Anannya and Basak, Susan and Bhattacharyya, Reema and Bhattacharyya, Debasish (2005) Reactivity of polyaminocarboxylatoruthenium(III) complexes with serine and their protease inhibition. Journal of Coordination Chemistry, 58 (18). pp. 1703-1711. ISSN 0095-8972 |
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| Relation |
http://dx.doi.org/10.1080/00958970500247487
http://www.eprints.iicb.res.in/325/ |
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