HnRNP E2 is Downregulated in Human Oral Cancer Cells and the Overexpression of hnRNP E2 Induces Apoptosis
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
HnRNP E2 is Downregulated in Human Oral Cancer Cells and the Overexpression of hnRNP E2 Induces Apoptosis
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| Creator |
Roychoudhury, Paromita
Paul, Ranjan Rashmi Chowdhury, Rajdeep Chaudhuri, Keya |
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| Subject |
Molecular & Human Genetics
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| Description |
Human hnRNP genes have been reported to be involved in human malignancies and several hnRNPs are promising
biomarkers of lung, head and neck, colon, breast, and pancreatic cancers. The present study investigated the
clinicopathologic and biological significance of hnRNP E2 gene expression in oral cancer. Human hnRNP E2 was
significantly downregulated in oral cancer tissues compared to normal one (P<0.0001) as determined by quantitative
real-time reverse transcription PCR. The expression of hnRNP E2 is correlated with histology, being lower in moderate
and poorly differentiated squamous cell carcinoma (SCC) compared to well-differentiated SCC. Transient transfection
of hnRNP E2 in cancerous cell lines resulted in reduced cell viability and increased apoptotic nuclei. Compared to
control transfectants, cells with higher expression showed an increase in the number of apoptotic cells by annexin-PI
staining and an increase in caspase activity. The present study thus implicates downregulation of hnRNP E2 as a novel
mechanism to enhance the resistance of cancer cells to apoptosis. � 2007 Wiley-Liss, Inc.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/340/1/MOLECULAR_CARCINOGENESIS%2C_46(_3)%2C_198%2D207_%2C2007_[105].pdf
Roychoudhury, Paromita and Paul, Ranjan Rashmi and Chowdhury, Rajdeep and Chaudhuri, Keya (2007) HnRNP E2 is Downregulated in Human Oral Cancer Cells and the Overexpression of hnRNP E2 Induces Apoptosis. Molecular Carcinogenesis, 46 (3). pp. 198-207. |
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| Relation |
http://dx.doi.org/10.1002/mc.20265
http://www.eprints.iicb.res.in/340/ |
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