Studies on the Synthesis of Modified Nucleosides Derived from Carbohydrate Based Chiral Precursors
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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Title |
Studies on the Synthesis of Modified Nucleosides
Derived from Carbohydrate Based Chiral
Precursors
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Creator |
Ghosh, Ramprasad
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Subject |
Chemistry
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Description |
This dissertation comprises mainly of two chapters. Chapter 1 (Part A) describes a synthetic
approach to cyclopentane ring containing carbanucleosides from easily accessible D-glucose
derived substrates via intramolecular nitrone cycloaddition (INC) reaction and Chapter 1 (Part B)
deals with various cyclopentane/cyclopentene carbocycles by means of intermolecular/
intramolecular Henry reaction starting again from D-glucose based precursors. Chapter II
demonstrates how, by applying ring closing metathesis (RCM) and INC reactions, could lead to
various locked bicycles and their eventual transformation to conformationally locked bicyclic
nucleosides including synthesis of enantiomeric nucleoside derivatives.
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Date |
2010
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Type |
Thesis
NonPeerReviewed |
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Format |
application/pdf
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Identifier |
http://www.eprints.iicb.res.in/350/1/Thesis_Ramprasad.pdf
Ghosh, Ramprasad (2010) Studies on the Synthesis of Modified Nucleosides Derived from Carbohydrate Based Chiral Precursors. PhD thesis, Jadavpur University. |
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Relation |
http://www.eprints.iicb.res.in/350/
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