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Molecular Mechanism of Insulin Resistance

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Field Value
 
Title Molecular Mechanism of Insulin Resistance
 
Creator Bhattacharya, Samir
Dey, Debleena
Roy, Sib Sankar
 
Subject Cell Biology & Physiology
 
Description Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby causing insulin resistanceNand type 2 diabetes. However, the underlying mechanism involved is still unclear. In searching for the cause of the mechanism, it has been found that palmitate inhibits insulin receptor (IR) gene expression, leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKCĪµ causes this reduction in insulin receptor gene expression. One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies. We provide an overview of this important area, emphasizing the current status.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/353/1/JOURNAL_OF_BIOSCIENCES%2C__32_(_2)%2C405%2D413%2C2007[108].pdf
Bhattacharya, Samir and Dey, Debleena and Roy, Sib Sankar (2007) Molecular Mechanism of Insulin Resistance. Journal of Biosciences, 32 (2). pp. 405-413.
 
Relation http://dx.doi.org/10.1007/s12038-007-0038-8
http://www.eprints.iicb.res.in/353/