Codon and Amino Acid Usage in Two Major Human Pathogens of Genus Bartonella — Optimization Between Replicational- Transcriptional Selection, Translational Control and Cost Minimization
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Codon and Amino Acid Usage in Two Major Human Pathogens
of Genus Bartonella — Optimization Between Replicational-
Transcriptional Selection, Translational Control and Cost
Minimization
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| Creator |
Das, Sabyasachi
Paul, Sandip Chatterjee, Sanjib Dutta, Chitra |
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| Subject |
Structural Biology & Bioinformatics
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| Description |
Intra-genomic variation in synonymous codon and amino acid usage in two human pathogens Bartonella
henselae and B. quintana has been carried out through multivariate analysis. Asymmetric mutational bias,
coupled with replicational-transcriptional selection, has been identified as the prime selection force behind
synonymous codon selection — a characteristic of the genus Bartonella, not exhibited by any other alphaproteobacterial
genome. Distinct codon usage patterns and low synonymous divergence values between
orthologous sequences of highly expressed genes from the two Bartonella species indicate that there exists
a residual intra-strand synonymous codon bias in the highly expressed genes, possibly operating at the
level of translation. In the case of amino acid usage, the mean hydropathy level and aromaticity are the
major sources of variation, both having nearly equal impact, while strand-specific mutational pressure
and gene expressivity strongly influence the inter-strand variations. In both species under study, the
highly expressed gene products tend not to contain heavy and/or aromatic residues, following the costminimization
hypothesis in spite of their intracellular lifestyle. The codon and amino acid usage in these two
human pathogens are, therefore, consequences of a complex balance between replicational-transcriptional
selection, translational control, protein hydropathy and cost minimization.
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| Date |
2005
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/368/1/DNA_RESEARCH_12_(2_)91%2D102_;2005[69].pdf
Das, Sabyasachi and Paul, Sandip and Chatterjee, Sanjib and Dutta, Chitra (2005) Codon and Amino Acid Usage in Two Major Human Pathogens of Genus Bartonella — Optimization Between Replicational- Transcriptional Selection, Translational Control and Cost Minimization. DNA Research, 12. pp. 91-102. |
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| Relation |
http://dx.doi.org/10.1093/dnares/12.2.91
http://www.eprints.iicb.res.in/368/ |
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