Inactivation of Human MutL Homolog 1 and MutS Homolog 2 Genes in Head and Neck Squamous Cell Carcinoma Tumors and Leukoplakia Samples by Promoter Hypermethylation and Its Relation With Microsatellite Instability Phenotype
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Inactivation of Human MutL Homolog 1 and MutS Homolog 2 Genes in Head and Neck Squamous Cell Carcinoma Tumors and Leukoplakia Samples by Promoter Hypermethylation and Its Relation With Microsatellite Instability Phenotype
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| Creator |
Sengupta, Shiladitya
Chakrabarti, Susmita Roy, Anup Panda, Chinmay Kumar Roychoudhury, Susanta |
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| Subject |
Molecular & Human Genetics
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| Description |
Head and neck squamous cell carcinoma (HNSCC) is the sixth
most common cancer in the world1 and accounts for 30% to
40% of all cancers in India.2 The major risk factors for this type of cancer are tobacco intake, both in the form of smoking and chewing, alcohol consumption, and human papillomavirus infection.HNSCC is characterized by complex, nonrandom changes in its genome and often shows different types of genomic instabilities.5,6 Previous investigators7–10 reported that a substantial fraction of HNSCC tumors
exhibits instability at the simple repeat sequences
(microsatellites) that are distributed throughout the
genome known as microsatellite instability (MIN).
In colorectal and other tumors, MIN occurs because
of defects in mismatch-repair (MMR) genes, such as
human mutL homolog 1 (hMLH1); human mutS homolog
1, 3, and 6 (hMSH2, hMSH3, and hMSH6); and
postmeiotic segregation increased 1 and 2 (PMSI and
PMS2).11–14 However, involvement of MMR genes
in the development of MIN in HNSCC tumors is
uncertain.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/371/1/CANCER%2C109(_4)%2C_703%2D712%2C2007_[112].pdf
Sengupta, Shiladitya and Chakrabarti, Susmita and Roy, Anup and Panda, Chinmay Kumar and Roychoudhury, Susanta (2007) Inactivation of Human MutL Homolog 1 and MutS Homolog 2 Genes in Head and Neck Squamous Cell Carcinoma Tumors and Leukoplakia Samples by Promoter Hypermethylation and Its Relation With Microsatellite Instability Phenotype. CANCER , 109 (4). pp. 703-712. |
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| Relation |
http://dx.doi.org/10.1002/cncr.22430
http://www.eprints.iicb.res.in/371/ |
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