Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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Title |
Therapeutic use of quercetin in the control of infection and anemia
associated with visceral leishmaniasis
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Creator |
Sen, Gargi
Mandal, Suparna Saha Roy, Sudipa Mukhopadhyay, Sibabrata |
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Subject |
Cell Biology & Physiology
Chemistry |
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Description |
Flavonoids are a broad class of plant phenolics that are known to possess a well-established protective effect against membrane
lipoperoxidative damages. Oxidative damage of erythrocytes has been implicated in the reduced survival of erythrocytes during leishmanial
infection. This study reveals the efficacy of five naturally occurring flavonoids in arresting the development of anemia during the
postinfection period. Among the compounds studied, quercetin was most successful in inhibiting the oxidation of proteins and lipids on the
red cell membranes of infected animals. Apart from its antianemic property, quercetin also seemed to be highly potent in lowering the parasite
load in the spleen. Combination therapy of quercetin with the antileishmanial drug stibanate produced a better decay of SOH in the
erythrocytes of the infected animals compared to that induced by quercetin or drug treatment alone. Similar results were obtained in
successful prevention of proteolytic degradation resulting in an aversion to early lysis of red cells after simultaneous treatment with quercetin
and stibanate. Subsequent studies demonstrated the therapeutic efficacy of the combination treatment in the abatement of both anemia and
parasitemia under the diseased condition
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Publisher |
Elsevier
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Date |
2005
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Type |
Article
PeerReviewed |
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Format |
application/pdf
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Identifier |
http://www.eprints.iicb.res.in/372/1/FREE_RADICAL_BIOLOGY_AND_MEDICINE__38(9)_1257%2D1264;2005[67].pdf
Sen, Gargi and Mandal, Suparna and Saha Roy, Sudipa and Mukhopadhyay, Sibabrata (2005) Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis. Free Radical Biology & Medicine, 38 (9). pp. 1257-1264. |
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Relation |
http://dx.doi.org/10.1016/j.freeradbiomed.2005.01.014
http://www.eprints.iicb.res.in/372/ |
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