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Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis
 
Creator Sen, Gargi
Mandal, Suparna
Saha Roy, Sudipa
Mukhopadhyay, Sibabrata
 
Subject Cell Biology & Physiology
Chemistry
 
Description Flavonoids are a broad class of plant phenolics that are known to possess a well-established protective effect against membrane lipoperoxidative damages. Oxidative damage of erythrocytes has been implicated in the reduced survival of erythrocytes during leishmanial infection. This study reveals the efficacy of five naturally occurring flavonoids in arresting the development of anemia during the postinfection period. Among the compounds studied, quercetin was most successful in inhibiting the oxidation of proteins and lipids on the red cell membranes of infected animals. Apart from its antianemic property, quercetin also seemed to be highly potent in lowering the parasite load in the spleen. Combination therapy of quercetin with the antileishmanial drug stibanate produced a better decay of SOH in the erythrocytes of the infected animals compared to that induced by quercetin or drug treatment alone. Similar results were obtained in successful prevention of proteolytic degradation resulting in an aversion to early lysis of red cells after simultaneous treatment with quercetin and stibanate. Subsequent studies demonstrated the therapeutic efficacy of the combination treatment in the abatement of both anemia and parasitemia under the diseased condition
 
Publisher Elsevier
 
Date 2005
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/372/1/FREE_RADICAL_BIOLOGY_AND_MEDICINE__38(9)_1257%2D1264;2005[67].pdf
Sen, Gargi and Mandal, Suparna and Saha Roy, Sudipa and Mukhopadhyay, Sibabrata (2005) Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis. Free Radical Biology & Medicine, 38 (9). pp. 1257-1264.
 
Relation http://dx.doi.org/10.1016/j.freeradbiomed.2005.01.014
http://www.eprints.iicb.res.in/372/